Synthesis and bio-evaluation of aminoferrocene-based anticancer prodrugs as potent ferroptosis inducers
Qianer Zhang, Xuejing Fan, Huimei Qian, Shanshan Xiao, Song Qin, Yicheng Wang, Yicheng Wang, Jing Wang, Shuang Yang, Yong Wang, Yong Wang
Abstract
Novel ROS-responsive N -alkylaminoferrocene (NAAF)-appended GPX4 inhibitors have been designed and prepared as potent ferroptosis-inducing prodrugs.
Topics & Concepts
ProdrugInducerChemistryAnticancer drugPharmacologyComputational biologyBiologyDrugBiochemistryGeneFerrocene Chemistry and ApplicationsFerroptosis and cancer prognosisPeptidase Inhibition and Analysis