Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer
Zixu Zhang, David Westover, Zhantong Tang, Yue Liu, Jinghan Sun, Yun-Xi Sun, Runqing Zhang, Xingyue Wang, Shihui Zhou, Nigaerayi Hesilaiti, Qi Xia, Zhenfang Du
Abstract
Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators, including proteins, miRNAs, lncRNAs, and circRNAs, have been found to promote or inhibit signaling by acting on Wnt proteins, receptors, signal transducers and transcriptional effectors. The identification of these regulators and their underlying molecular mechanisms provides important implications for how to target this pathway therapeutically. In this review, we summarize recent studies of Wnt regulators in the development and therapeutic response of NSCLC.