Chlorogenic acid ameliorates <i>Klebsiella pneumoniae</i>-induced pneumonia in immunosuppressed mice <i>via</i> inhibiting the activation of NLRP3 inflammasomes
Junhao Zeng, Xiaoyu Wan, Ting Liu, Ying Xiong, Gan Xiang, Yali Peng, Ronghua Zhu, Yong-qin Zhou, Chaoqi Liu
Abstract
Utilizing the inflammatory response models both in vivo and in vitro , we demonstrated that the dietary intake of chlorogenic acid ameliorated K. pneumonia -induced pneumonia via inhibiting the activation of the NLRP3 inflammasome.
Topics & Concepts
MicrobiologyKlebsiella pneumoniaeIn vivoInflammationTumor necrosis factor alphaLipopolysaccharideImmunologyChemistryBiologyBiochemistryEscherichia coliBiotechnologyGeneInflammasome and immune disordersImmune Response and InflammationImmune cells in cancer