Sulfonamide derivatives of cis-imidazolines as potent p53-MDM2/MDMX protein-protein interaction inhibitors
Daniil R. Bazanov, Nikolay V. Pervushin, Egor V. Savin, Michael D. Tsymliakov, Anita I. Maksutova, S. E. Sosonyuk, Gelina S. Kopeina, Natalia A. Lozinskaya
Topics & Concepts
ChemistryMDMXSulfonylSubstituentAlkoxy groupMdm2SolubilitySulfonamideStereochemistryA549 cellCombinatorial chemistryBiochemistryIn vitroAlkylOrganic chemistryApoptosisCancer-related Molecular PathwaysClick Chemistry and ApplicationsHIV/AIDS drug development and treatment