Selective and stoichiometric incorporation of ATP by self-assembling amyloid fibrils
Robert Dec, Wojciech Puławski, Wojciech Dzwolak
Abstract
ATP storage) emerge from synergistic coupling of amyloidogenic segments with non-amyloidogenic peptide ligands, and suggest that ATP's role in protein misfolding is more nuanced than previously assumed.
Topics & Concepts
FibrilPeptideAdenosine triphosphateMonomerBiophysicsBiochemistryAmyloid (mycology)ChemistryAmyloid fibrilPeptide sequenceAmino acidBiologyAmyloid βPolymerMedicineInorganic chemistryDiseaseGeneOrganic chemistryPathologySupramolecular Self-Assembly in MaterialsProtein Structure and DynamicsChemical Synthesis and Analysis