Adduct of Aquacobalamin with Hydrogen Peroxide
Maria Lehene, Diana Pleșa, Stefania Ionescu-Zinca, Ștefania D. Iancu, Nicolae Leopold, Sergei V. Makarov, Adrian M. V. Brânzanic, Radu Silaghi‐Dumitrescu
Abstract
Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant, as evidenced by UV-vis absorption spectroscopy and corroborated by NMR, Raman spectroscopy, stopped-flow UV-vis measurements, and density functional theory calculations.
Topics & Concepts
ChemistryAdductHydrogen peroxideRaman spectroscopyPhotochemistryDissociation (chemistry)PeroxideSpectroscopyAbsorption spectroscopyDensity functional theoryResonance Raman spectroscopyDissociation constantCobaltNuclear magnetic resonance spectroscopyInorganic chemistryPhysical chemistryStereochemistryComputational chemistryOrganic chemistryReceptorOpticsPhysicsQuantum mechanicsBiochemistryAdvanced oxidation water treatmentPorphyrin Metabolism and DisordersPorphyrin and Phthalocyanine Chemistry