Late-stage functionalisation of alkyne-modified phospha-xanthene dyes: lysosomal imaging using an off–on–off type of pH probe
Hiroaki Ogasawara, Y. Tanaka, Masayasu Taki, Shigehiro Yamaguchi
Abstract
a late-stage Cu-catalysed azide/alkyne cycloaddition (CuAAC) reaction, thus achieving target-selective labelling. To demonstrate the practical utility of the functionalised POXs, we designed a sophisticated NIR probe that exhibits a bell-shaped off-on-off pH-response and is able to assess the degree of endosomal maturation.
Topics & Concepts
XantheneAlkyneFluorescenceChemistryOrganelleCombinatorial chemistryNanotechnologyPhotochemistryMaterials scienceOrganic chemistryBiochemistryPhysicsCatalysisQuantum mechanicsLuminescence and Fluorescent MaterialsMolecular Sensors and Ion DetectionNanoplatforms for cancer theranostics