Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages
Deyanira Pérez-Morales, Vı́ctor H. Bustamante
Abstract
Replication inside macrophages is crucial for systemic dissemination of Salmonella in hosts. In a Nature Communications article, Jiang et al. show that Salmonella stimulates glycolysis and represses serine synthesis in macrophages, leading to accumulation of host glycolytic intermediates that the bacteria use as carbon source and as cues for its replication.
Topics & Concepts
SalmonellaReplication (statistics)GlycolysisSerineMicrobiologyBacteriaCell biologyMacrophageBiologyChemistryMetabolismGeneticsVirologyPhosphorylationBiochemistryIn vitroSalmonella and Campylobacter epidemiologyVibrio bacteria research studiesCancer Research and Treatments