Manganese(III) Acetate Catalyzed Aerobic Dehydrogenation of Tertiary Indolines, Tetrahydroquinolines and an <i>N</i>‐Unsubstituted Indoline
Xiaokang Niu, Lei Yang
Abstract
Abstract A Mn(OAc) 3 ⋅ 2H 2 O‐catalyzed aerobic dehydrogenation of five and six‐membered N ‐heterocycles for the synthesis of N ‐heteroarenes is reported. Of note, this protocol can be applied to the dehydrogenation of tertiary indolines with various electron‐deficient N ‐substituents. Preliminary mechanistic investigations support that a single‐electron transfer pathway might be involved. magnified image
Topics & Concepts
DehydrogenationChemistryIndolineCatalysisManganeseManganese(III) acetateMedicinal chemistryOrganic chemistryAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions