Clinical Implementation of Rare and Novel<i> DPYD</i> Variants for Personalizing Fluoropyrimidine Treatment: Challenges and Opportunities
Elena De Mattia, Noemi Milan, Yehuda G. Assaraf, Giuseppe Toffoli, Erika Cecchin
Abstract
sequence, including rare and novel genetic variants, may significantly enhance the pre-emptive identification of at-risk patients, compared to the current targeted approach.
Topics & Concepts
DPYDComputational biologyMedicinePharmacologyInternal medicineGeneticsBiologyPharmacogeneticsGenotypeGeneBiochemical and Molecular ResearchColorectal Cancer Treatments and StudiesMedical Imaging Techniques and Applications