A light-activatable photosensitizer for photodynamic therapy based on a diarylethene derivative
Jian Zhang, Ran Zhang, Kaiqiang Liu, Yong Li, Xu Wang, Xilei Xie, Xiaoyun Jiao, Bo Tang
Abstract
Herein, a light-activatable photosensitizer based on a diarylethene derivative, DAE-TPE, was developed for photodynamic therapy. Upon UV exposure, the "opened" form (OF) of DAE-TPE NPs was converted to the "closed" form (CF), and photosensitization was activated. The CF of DAE-TPE NPs exhibited sufficient photodynamic therapy effects upon HeLa cells.
Topics & Concepts
DiarylethenePhotosensitizerPhotodynamic therapyDerivative (finance)PhotochemistryChemistryPhotochromismOrganic chemistryEconomicsFinancial economicsPhotochromic and Fluorescence ChemistryLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranostics