Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis
Robert R. A. Bolt, Jamie A. Leitch, Andrew C. Jones, William I. Nicholson, Duncan L. Browne
Abstract
Rapid and wide-ranging developments have established mechanochemistry as a powerful avenue in sustainable organic synthesis. This is primarily due to unique opportunities which have been offered in solvent-free - or highly solvent-minimised - reaction systems. Nevertheless, despite elegant advances in ball-milling technology, limitations in scale-up still remain. This tutorial review covers the first reports into the translation from "batch-mode" ball-milling to "flow-mode" reactive extrusion, using twin-screw extrusion.
Topics & Concepts
MechanochemistryExtrusionReactive extrusionContinuous flowOrganic synthesisFlow (mathematics)NanotechnologyChemistryMaterials scienceProcess engineeringBiochemical engineeringOrganic chemistryEngineeringMetallurgyMechanicsCatalysisPhysicsInnovative Microfluidic and Catalytic Techniques InnovationChemistry and Chemical EngineeringNanofabrication and Lithography Techniques