Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders
Bijo Mathew, Jong‐Min Oh, Roua S. Baty, Gaber El‐Saber Batiha, Della Grace Thomas Parambi, Nicola Gambacorta, Orazio Nicolotti, Hoon Kim
Topics & Concepts
ChemistryPiperazineAcetylcholinesteraseIC50AchéADMEEnzymeStereochemistryActive siteMonoamine neurotransmitterPharmacologyBiochemistryIn vitroOrganic chemistryMedicineSerotoninReceptorCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsElectrochemical sensors and biosensors