CeO2 nanohybrid as a synergist for insecticide resistance management
Qinghong Zeng, Chang Yu, Xuanli Chang, Yue Wan, Yulong Ba, Chengyue Li, Haixiang Lv, Zhimin Guo, Tingwei Cai, Zhijie Ren, Yao Qin, Yunhua Zhang, Kangsheng Ma, Jianhong Li, Shun He, Hu Wan
Abstract
Agricultural applications of nanomaterials, such as nanofertilizers, nanopreservation technologies, nanopesticides, and plant nanosensors, have recently attracted much attention. Herein, the CeO 2 -based nanohybrid MON@CeO 2 was designed as a reactive oxygen species (ROS) inhibitor to effectively improve the susceptibility of insect pests to insecticides. MON@CeO 2 was fabricated by intercalating CeO 2 into mesoporous organosilica nanoparticles (MONs). The obtained MON@CeO 2 showed a regular spherical shape with an average particle size of 45.4 nm, good monodispersity, and a negative surface charge (-14.6 mV). Bioassay results showed that MON@CeO 2 significantly enhanced the toxicity (more than 2-fold) of nitenpyram, sulfoxaflor, and clothianidin against laboratory insecticide-resistant and field strains of Nilaparvata lugens . In particular, MON@CeO 2 orchestrated host detoxification metabolism via downregulating ROS-dependent P450 gene expression, thus reducing host detoxification enzyme activities to overcome insecticide resistance . Furthermore, MON@CeO 2 restrained host insecticide resistance in the notorious agricultural pests Aphis gossypii , Spodoptera frugiperda , and Sogatella furcifera . Therefore, MON@CeO 2 could be used as a broad-spectrum nanosynergist against insecticide resistance, which would be a novel strategy for sustainable pest management.