Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver
Cory D. Sago, Melissa P. Lokugamage, David Loughrey, Kevin E. Lindsay, Robert Hincapie, Brandon R. Krupczak, Sujay Kalathoor, Manaka Sato, Elisa Schrader Echeverri, Jordan P. Fitzgerald, Zubao Gan, Lena Gamboa, Kalina Paunovska, Carlos Sanhueza, Marine Z. C. Hatit, M. G. Finn, Philip J. Santangelo, James E. Dahlman
Topics & Concepts
Subgenomic mRNAOligonucleotideSmall interfering RNACas9BiologyCell biologyMolecular biologyIn vivoRNACRISPRChemistryGeneBiochemistryGeneticsRNA Interference and Gene DeliveryCRISPR and Genetic EngineeringRNA regulation and disease