Roflumilast protects from cisplatin-induced testicular toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. Role of NF-κB-p65, cAMP/PKA and Nrf2/HO-1, NQO1 signaling
Basel A. Abdel‐Wahab, Ismail A. Walbi, Hassan A. Albarqi, Fares E.M. Ali, Emad H. M. Hassanein
Topics & Concepts
RoflumilastChemistryApoptosisOxidative stressCytotoxicityCancer researchPharmacologyEndocrinologyInternal medicineBiologyMedicineIn vitroBiochemistryCOPDChemotherapy-induced organ toxicity mitigationReproductive Biology and FertilityReproductive System and Pregnancy