Liposome leakage and increased cellular permeability induced by guanidine-based oligomers: effects of liposome composition on liposome leakage and human lung epithelial barrier permeability
Yeonjeong Ha, Yerim Koo, Seon-Kyung Park, Gaeun Kim, Han Bin Oh, Ha Ryong Kim, Jung‐Hwan Kwon
Abstract
-mimicking liposomes. These results indicated that human cells are susceptible to guanidine-based oligomers. Considering that the interaction of oligomers and cell membranes is a major mechanism of toxicity initiation, this study provides crucial insights into the action of these disinfectants on mammalian cells.
Topics & Concepts
LiposomeGuanidineOligomerChemistryBiophysicsMembraneBiochemistryOrganic chemistryBiologyAntimicrobial agents and applicationsAntimicrobial Peptides and ActivitiesInhalation and Respiratory Drug Delivery