Astaxanthin targets IL-6 and alleviates the LPS-induced adverse inflammatory response of macrophages
Yahui Wu, Mona Alrasheed Bashir, Changsheng Shao, Han Wang, Jianxia Zhu, Qing Huang
Abstract
calculations based on molecular docking, molecular dynamics simulation, we identified interleukin-6 (IL-6) as a prominent core target of AST anti-inflammation, which was further validated by the RNA interference experiment. This IL-6 binding capacity actually enabled AST to curb the positive feedback loop of inflammatory factors, averting the onset of possible inflammatory storms. Therefore, this study offers a new possibility for the application and development of astaxanthin as a popular dietary supplement of anti-inflammatory or immunomodulatory function.
Topics & Concepts
AstaxanthinInflammatory responseAdverse effectLipopolysaccharideInflammationImmunologyMacrophageMedicinePharmacologyChemistryMicrobiologyBiologyBiochemistryIn vitroCarotenoidAntioxidant Activity and Oxidative StressAdipokines, Inflammation, and Metabolic DiseasesVitamin C and Antioxidants Research