Synthesis and evaluation of new chalcones and oximes as anticancer agents
Syed Nasir Abbas Bukhari
Abstract
configuration, in place of carbonyl functional group, along with a 2-phenyl thiophenyl moiety with or without a bromo group at position-5. The possible binding pattern was implied by docking simulation, inferring the possibility of introducing interactions with the nearby tubulin chain. Since the novel structural trial has been conducted with a detailed structure activity relationship discussion, this work might stimulate new ideas in further modification of multitarget anti-cancer agents and therapeutic approaches.
Topics & Concepts
Combinatorial chemistryChemistryBiochemical engineeringComputer scienceEngineeringSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsComputational Drug Discovery Methods