Exercise reduces the protein abundance of TXNIP and its interacting partner REDD1 in skeletal muscle: potential role for a PKA-mediated mechanism
Alec Chaves, Edwin R. Miranda, Jacob T. Mey, Brian K. Blackburn, Kelly N. Z. Fuller, Blaise Stearns, Andrew D. Ludlow, David L. Williamson, Joseph A. Houmard, Jacob M. Haus
Abstract
Aerobic exercise is an effective tool in the prevention and treatment of several chronic metabolic diseases. However, the mechanisms through which these benefits are conferred have yet to be fully elucidated. Our data reveal a novel effect of aerobic exercise on reducing the protein expression of molecular targets that negatively impact redox and insulin/growth signaling in skeletal muscle. These findings contribute to the expanding repository of molecular signatures provoked by aerobic exercise.
Topics & Concepts
TXNIPThioredoxin-Interacting ProteinPhosphorylationThioredoxinEndocrinologySerineSkeletal muscleInternal medicineSignal transductionChemistryCell biologyBiologyMedicineOxidative stressRedox biology and oxidative stressExercise and Physiological ResponsesHeat shock proteins research