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Identification of 3-aryl-5-methyl-isoxazole-4-carboxamide derivatives and analogs as novel HIF-2α agonists through docking-based virtual screening and structural modification

Siyuan Chen, Yao Liu, Zhe Wang, Chengcheng Qi, Yanzhen Yu, Lei Xu, Tingjun Hou, Rong Sheng

2024European Journal of Medicinal Chemistry10 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryIsoxazoleCarboxamideDocking (animal)Virtual screeningLead compoundPharmacologyAgonistErythropoietinStereochemistryIn vitroBiochemistryReceptorDrug discoveryInternal medicineMedicineNursingCancer, Hypoxia, and MetabolismCancer-related Molecular PathwaysMetabolism, Diabetes, and Cancer
Identification of 3-aryl-5-methyl-isoxazole-4-carboxamide derivatives and analogs as novel HIF-2α agonists through docking-based virtual screening and structural modification | Litcius