Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy
Alessio Nocentini, Vincenzo Alterio, Silvia Bua, Laura Micheli, Davide Esposito, Martina Buonanno, Gianluca Bartolucci, Sameh M. Osman, Zeid A. ALOthman, Roberto Cirilli, Marco Pierini, Simona Maria Monti, Lorenzo Di Cesare Mannelli, Paola Gratteri, Carla Ghelardini, Giuseppina De Simone, Claudiu T. Supuran
Abstract
)-enantiomer, allowed to halve the dose totally relieving allodynia in mice.
Topics & Concepts
ChemistryThio-PharmacologyAllodyniaOxaliplatinBiochemistryHyperalgesiaStereochemistryInternal medicineNociceptionMedicineReceptorCancerColorectal cancerEnzyme function and inhibitionCancer Treatment and PharmacologyCholinesterase and Neurodegenerative Diseases