PP2A subunit PPP2R2C is downregulated in the brains of Alzheimer’s transgenic mice
Waiian Leong, Wei Xu, Bo Wang, Shuaiyun Gao, Xiuyun Zhai, Cuicui Wang, Éric Gilson, Jing Ye, Yiming Lu
Abstract
expression regulates PP2A activity and tau dephosphorylation. These results suggest that dysregulation of PPP2R2C expression may be involved in the onset of AD and that specifically targeting PPP2R2C expression or activity is a promising strategy against brain dementia disorders, including AD and other tauopathies.
Topics & Concepts
Protein phosphatase 2DephosphorylationProtein subunitPhosphataseGenetically modified mouseBiologyTransgeneCell biologyGene expressionDementiaPhosphorylationGeneNeuroscienceGeneticsMedicineDiseaseInternal medicineAlzheimer's disease research and treatmentsGenetics and Neurodevelopmental DisordersMitochondrial Function and Pathology