Isolation and synthesis of cryptosanguinolentine (isocryptolepine), a naturally-occurring bioactive indoloquinoline alkaloid
Elida N. Thobokholt, Enrique L. Larghi, Andrea B. J. Bracca, Teodoro S. Kaufman
Abstract
. The natural product displays such a simple and unique skeleton, which chemists became interested in well before it was found in Nature. Because of its structure and biological activity, the natural product has been targeted for synthesis on numerous occasions, employing a wide range of different strategies. Hence, discussed here are aspects related to the isolation of isocryptolepine, as well as the various approaches toward its total synthesis.
Topics & Concepts
Isolation (microbiology)Natural productAlkaloidChemistryCombinatorial chemistryStereochemistryBiologyBioinformaticsSynthesis and bioactivity of alkaloidsSynthesis and pharmacology of benzodiazepine derivativesSynthesis and Reactivity of Heterocycles