Liposomes loaded with lipophilic derivative of closo-carborane as a potential boron delivery system for boron neutron capture therapy of tumors
Alphiya R. Tsygankova, Dmitry А. Gruzdev, В. В. Каныгин, Tatiana Y. Guselnikova, Angelina A. Telegina, А. I. Kasatova, A. I. Kichigin, Галина Л. Левит, Ludmila V. Mechetina, R. А. Mukhamadiyarov, И. А. Разумов, Olga I. Solovieva, Olga Y. Volkova, Andrey Ponomarev, В. П. Краснов, E. L. Zavjalov
Abstract
Liposomes encapsulated with lipophilic derivative of 1,2-dicarba-closo-dodecaborane have been obtained and tested for toxicity to glioblastoma U87 cells and biodistribution on a U87MG xenograft mouse model. The liposomes are able to penetrate the tumor and provide boron concentration up to 1.5 mmmmg g–1 with tumor-to-muscle ratio up to 2.4.
Topics & Concepts
BiodistributionLiposomeChemistryCarboraneBoronNeutron captureRadiochemistryDerivative (finance)PharmacologyToxicityBiophysicsCombinatorial chemistryStereochemistryBiochemistryOrganic chemistryIn vitroBiologyMedicineEconomicsFinancial economicsBoron Compounds in ChemistryRadiopharmaceutical Chemistry and ApplicationsRadiation Therapy and Dosimetry