Copper(<scp>ii</scp>) complexes of 2-methyl-8-hydroxyquinoline and tri/diimine co-ligand: DFT calculations, DNA and BSA binding, DNA cleavage, cytotoxicity and induction of apoptosis
Somasundaram Sangeetha, Tamilarasan Ajaykamal, Mariappan Murali
Abstract
Four-coordinate copper(<sc>ii</sc>) complex cleaves supercoiled ϕX174 RF DNA without reductant while five-coordinate complex cleaves with reductant. The cytotoxicity against cancer cells are higher than cisplatin, less-toxic to normal cells and induce apoptosis.
Topics & Concepts
ChemistryCytotoxicityDiimineDNA8-HydroxyquinolineCleavage (geology)ApoptosisLigand (biochemistry)CopperCisplatinStereochemistryPhotochemistryBiophysicsIn vitroBiochemistryReceptorInorganic chemistryOrganic chemistryFracture (geology)MedicineBiologyGeotechnical engineeringSurgeryEngineeringCatalysisChemotherapyMetal complexes synthesis and propertiesSynthesis and Characterization of Heterocyclic CompoundsDNA and Nucleic Acid Chemistry