Iron(II)-Catalyzed Bisphosphorylation Cascade Cycloisomerization of γ-Hydroxyl Ynones and Diphenylphosphine Oxides: Synthesis of Highly Substituted Bisphosphorylated Dihydrofuran Derivatives
Yi‐Feng Qiu, Shi‐Peng Chen, Jian-He Cao, Ming Li, Zheng‐Jun Quan, Xi‐Cun Wang, Yong‐Min Liang
Abstract
An iron(II)-catalyzed bisphosphorylation cascade cycloisomerization of readily accessible γ-hydroxyl ynones and diphenylphosphine oxides is described. This strategy provides a variety of valuable polysubstituted bisphosphorylated dihydrofuran scaffolds via the construction of two C-P bonds and one C-O bond within a single procedure. This developed reaction system demonstrates good functional group compatibilities with considerably low catalyst consumption (as low as 1%), which could be further scaled up to gram quantities in satisfactory yields.
Topics & Concepts
CycloisomerizationDiphenylphosphineChemistryCatalysisCascadeDiphenylphosphine oxideFunctional groupCombinatorial chemistryOrganic chemistryPhosphinePolymerChromatographyCatalytic Alkyne ReactionsCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods