Assessment of Mortality-Related Risk Factors and Effective Antimicrobial Regimens for Treatment of Bloodstream Infections Caused by Carbapenem-Resistant <i>Enterobacterales</i>
Liang Chen, Xiudi Han, YanLi Li, Minghui Li
Abstract
Bloodstream infections (BSIs) attributable to carbapenem-resistant Enterobacterales (CRE-BSIs) are dangerous and a major cause of mortality in clinical settings. This study was therefore designed to define risk factors linked to 30-day mortality in CRE-BSI patients and to examine the relative efficacies of different antimicrobial treatment regimens in affected individuals.
Topics & Concepts
MedicineAntimicrobialBacteremiaInternal medicineRelative riskRegimenConfoundingConfidence intervalLogistic regressionMeropenemIntensive care medicineMortality rateAntibioticsRisk factorRisk of mortalityAntibacterial agentProportional hazards modelRetrospective cohort studyMultivariate analysisOdds ratioFungemiaSurgeryLower riskCarbapenemPharmacotherapyCombination therapyAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyAntibiotic Use and Resistance