Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and roles in disease
S. M. J. Park, Mark M. Painter, Sasikanth Manne, Víctor Alcalde, Maura McLaughlin, Matthew Sullivan, Divij Mathew, Leonel Torres, Yinghui Huang, David B. Reeg, Naomi R. Douek, Trenton D. Campos, Max Klapholz, Maria A. Cardenas, Victoria Fang, Shin Foong Ngiow, Wumesh KC, Rishi R. Goel, Amy E. Baxter, J. W. Wu, Melody T. Tan, Corbett T. Berry, Christoph T. Ellebrecht, Alexander C. Huang, Emily Papazian, Ying Liu, Karthik Rajasekaran, Robert M. Brody, Erica R. Thaler, Devraj Basu, Ahmed Diab, Josephine R. Giles, E. John Wherry
Topics & Concepts
AntigenCD40BiologyInterleukin 21Antigen-presenting cellCell biologyImmunologyImmune systemDiseaseFunction (biology)Cytotoxic T cellInterleukin 3T cellNatural killer T cellInterleukin 12Antigen presentationStimulationZAP70Naive B cellIL-2 receptorCellCancer researchT lymphocyteB-1 cellCD28T-cell and B-cell ImmunologyCancer Immunotherapy and BiomarkersSingle-cell and spatial transcriptomics