Repression of <i>Osmr</i> and <i>Fgfr1</i> by <i>miR-1/133a</i> prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart
Melissa Valussi, Johannes Besser, Katharina Wystub-Lis, Sven Zukunft, Manfred Richter, Thomas Kubin, Thomas Boettger, Thomas Braun
Abstract
The muscle-specific miR-1 and miR-133a RNAs lock cardiomyocytes in a differentiated state by suppressing OSMR/FGFR signaling.
Topics & Concepts
Psychological repressionCell biologyCellSignal transductionCell cycleBiologyChemistryGeneticsGeneGene expressionCongenital heart defects researchTissue Engineering and Regenerative MedicineRNA modifications and cancer