Escherichia coli Genomic Diversity within Extraintestinal Acute Infections Argues for Adaptive Evolution at Play
Antoine Bridier‐Nahmias, Adrien Launay, Alexandre Bleibtreu, Mélanie Magnan, Violaine Walewski, Jérémie Chatel, Sara Dion, Véronique Robbe‐Saule, Olivier Clermont, Françoise Norel, Érick Denamur, Olivier Tenaillon
Abstract
Little is known about the dynamics of adaptation in acute bacterial infections. By sequencing multiple isolates from monoclonal extraintestinal Escherichia coli infections in several patients, we were able to uncover traces of selection taking place at short time scales compared to chronic infection.
Topics & Concepts
Escherichia coliBiologyAdaptation (eye)Positive selectionMicrobiologySelection (genetic algorithm)Diversity (politics)Adaptive evolutionGeneticsComputational biologyGeneArtificial intelligenceSociologyComputer scienceAnthropologyNeuroscienceEvolution and Genetic DynamicsEscherichia coli research studiesGut microbiota and health