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ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

Víctor A. Arrieta, Andrew Chen, J. Robert Kane, Seong Jae Kang, Cynthia Kassab, Crismita Dmello, Junfei Zhao, Kirsten B. Burdett, Pavan S. Upadhyayula, Catalina Lee-Chang, Joseph Shilati, Dinesh Jaishankar, Li Chen, Andrew Gould, Daniel Y. Zhang, Jinzhou Yuan, Wenting Zhao, Xiaoyang Ling, Jared K. Burks, Brice Laffleur, Christina Amidei, Jeffrey N. Bruce, Rimas V. Lukas, Jonathan T. Yamaguchi, David Cieremans, Gerson Rothschild, Uttiya Basu, Matthew McCord, Daniel J. Brat, Hui Zhang, Lee Cooper, Bin Zhang, Peter A. Sims, Tim Cloughesy, Robert M. Prins, Peter Canoll, Roger Stupp, Amy B. Heimberger, Craig Horbinski, Fábio M. Iwamoto, Raúl Rabadán, Adam M. Sonabend

2021Nature Cancer120 citationsDOIOpen Access PDF

Topics & Concepts

MAPK/ERK pathwayNeuroblastoma RAS viral oncogene homologCancer researchImmunotherapyPhosphorylationPTPN11MedicineBlockadeBiologyImmunologyInternal medicineImmune systemCancerKRASCell biologyReceptorColorectal cancerGlioma Diagnosis and TreatmentImmune cells in cancerNeuroinflammation and Neurodegeneration Mechanisms
ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma | Litcius