SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk
Ryan Green, Karthick Mayilsamy, Andrew R. McGill, Taylor E. Martinez, Bala Chandran, Laura J. Blair, Paula C. Bickford, Shyam S. Mohapatra, Subhra Mohapatra
Abstract
, and complement genes C4 and C5AR1. Brain histopathology shows AD signatures including increased tau-phosphorylation, tau-oligomerization, and α-synuclein expression in aged MA10 infected mice. The results of gene expression profiling of SARS-CoV-2-infected and AD brains and studies in the MA10 aged mouse model taken together, for the first time provide evidence suggesting that SARS-CoV-2 infection alters expression of genes in the brain associated with the development of AD. Future studies of common molecular markers in SARS-CoV-2 infection and AD could be useful for developing novel therapies targeting AD.