Enhanced sciatic nerve regeneration by relieving iron-overloading and organelle stress with the nanofibrous P(MMD-co-LA)/DFO conduits
Lei Han, Xianzhen Dong, Tong Qiu, Zhaona Dou, Lin Wu, Honglian Dai
Abstract
, PDPLA/DFO conduits constructed the anti-inflammatory microenvironment and promoted cell survival by alleviating iron overload and organelle stress. In conclusion, PDPLA/DFO guidance conduits targeted the distal iron overload and promoted nerve regeneration. It provides novel ideas for designing nerve conduits targeting the distal microenvironment.
Topics & Concepts
Regeneration (biology)ChemistryCell biologyOxidative stressReactive oxygen speciesGlutathioneMitochondrionBiochemistryBiologyEnzymeNerve injury and regenerationElectrospun Nanofibers in Biomedical ApplicationsGraphene and Nanomaterials Applications