Multidrug Resistant Tuberculosis With Simultaneously Acquired Drug Resistance to Bedaquiline and Delamanid
Takashi Yoshiyama, Akiko Takaki, Akio Aono, Satoshi Mitarai, Masao Okumura, Ken Ohta, Seiya Kato
Abstract
This study is the first to report a clinical case of simultaneously acquired resistance to bedaquiline (BDQ) and delamanid (DLM). Whole genome sequencing revealed 2 nucleotide insertions (Rv0678 and fbiC) in the Mycobacterium tuberculosis isolate. The minimum inhibitory concentrations for BDQ and DLM were 0.25 µg/mL and >2.0 µg/mL, respectively.
Topics & Concepts
BedaquilineMedicineTuberculosisMycobacterium tuberculosisDrug resistanceMultiple drug resistanceMicrobiologyVirologyBiologyPathologyTuberculosis Research and EpidemiologyCancer therapeutics and mechanismsAntibiotic Resistance in Bacteria