Quantification of crystallinity during indomethacin crystalline transformation from α- to γ-polymorphic forms and of the thermodynamic contribution to dissolution in aqueous buffer and solutions of solubilizer
Kanji Hasegawa, Satoru Goto, Hikaru Kataoka, Hitoshi Chatani, Takatoshi Kinoshita, Hideshi Yokoyama, Tomohiro Tsuchida
Abstract
, respectively, which are in agreement with the quantitative contribution predicted by the product of the temperature and melting entropy. The contribution of melting entropy was conserved in different dissolution processes with aqueous solvents containing lidocaine, diltiazem, l-carnosine, and aspartame as solubilizers; their γ-form Setschenow coefficients were -39.6, +82.9, -17.3, and +23.2, whereas those of the α-form were -39.7, +80.4, -16.7, and +22.7, respectively. We conclude that the dissolution ability of the solid state and solubilizers indicate their additivity independently.
Topics & Concepts
DissolutionCrystallinitySolubilizationAqueous solutionTransformation (genetics)ChemistryBuffer (optical fiber)Chemical engineeringThermodynamicsOrganic chemistryCrystallographyBiochemistryEngineeringGeneComputer sciencePhysicsTelecommunicationsCrystallization and Solubility StudiesDrug Solubulity and Delivery SystemsCrystallography and molecular interactions