SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers
Noah H. Somberg, Westley W. Wu, João Medeiros‐Silva, Aurelio J. Dregni, Hyunil Jo, William F. DeGrado, Mei Hong
Abstract
F spins are within a detectable distance of about 2 nm, suggesting that the ETM pentamers cluster in the lipid bilayer. Monte Carlo simulations that take into account peptide-peptide and peptide-lipid interactions yielded pentamer clusters that reproduced the CODEX data. This supramolecular organization is likely important for E-mediated virus assembly and budding and for the channel function of the protein.
Topics & Concepts
PentamerLipid bilayerPeptideChemistryEndoplasmic reticulumBiophysicsTransmembrane proteinMembraneCrystallographyBiochemistryBiologyReceptorLipid Membrane Structure and BehaviorAdvanced NMR Techniques and ApplicationsProtein Structure and Dynamics