MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
Nao Hondo, Masato Kitazawa, Makoto Koyama, Satoshi Nakamura, Shigeo Tokumaru, Satoru Miyazaki, Masahiro Kataoka, Kai Seharada, Yuji Soejima
Topics & Concepts
CetuximabKRASMEK inhibitorMAPK/ERK pathwayTrametinibEGFR inhibitorsColorectal cancerCancer researchEpidermal growth factor receptorPanitumumabMedicineCancerGrowth inhibitionPharmacologyKinaseCell cultureBiologyInternal medicineCell biologyGeneticsColorectal Cancer Treatments and StudiesPI3K/AKT/mTOR signaling in cancerMelanoma and MAPK Pathways