Minocycline, a classic antibiotic, exerts psychotropic effects by normalizing microglial neuroinflammation-evoked tryptophan-kynurenine pathway dysregulation in chronically stressed male mice
Dan Cheng, Zongshi Qin, Yu Zheng, Jun-Ya Xie, Suisha Liang, Jialing Zhang, Yibin Feng, Zhang‐Jin Zhang
Topics & Concepts
MinocyclineKynurenineNeuroinflammationQuinolinic acidKynurenine pathwayPharmacologyIndoleamine 2,3-dioxygenaseNeuroprotectionKynurenic acidChemistryInternal medicineMedicineInflammationTryptophanBiochemistryGlutamate receptorAntibioticsReceptorAmino acidTryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol