The Quest for the Ideal Base: Rational Design of a Nickel Precatalyst Enables Mild, Homogeneous C–N Cross-Coupling
Richard Y. Liu, Joseph M. Dennis, Stephen L. Buchwald
Abstract
of the Ni-bound amine and the barrier to reductive elimination from the resultant Ni(II)-amido complex. Moreover, we determined that the preclusion of Lewis acid-base complexation between the Ni catalyst and the base, due to steric factors, is important for avoiding catalyst inhibition.
Topics & Concepts
ChemistrySteric effectsArylTriethylamineCatalysisPhosphineDenticityNucleophileAminationBase (topology)Combinatorial chemistryPalladiumHomogeneous catalysisLigand (biochemistry)Catalytic cycleAmine gas treatingCoupling reactionNickelOrganic chemistryCrystal structureReceptorAlkylMathematicsMathematical analysisBiochemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis