Th2A cells: The pathogenic players in allergic diseases
Ziyu Huang, M. C. Chu, Xi Chen, Ziyuan Wang, Jiang Lin, Yinchao Ma, Yuedan Wang
Abstract
Proallergic type 2 helper T (Th2A) cells are a subset of memory Th2 cells confined to atopic individuals, and they include all the allergen-specific Th2 cells. Recently, many studies have shown that Th2A cells characterized by CD3 + CD4 + HPGDS + CRTH2 + CD161 high ST2 high CD49d high CD27 low play a crucial role in allergic diseases, such as atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), asthma, and eosinophilic esophagitis (EoE). In this review, we summarize the discovery, biomarkers, and biological properties of Th2A cells to gain new insights into the pathogenesis of allergic diseases.
Topics & Concepts
Eosinophilic esophagitisAtopic dermatitisImmunologyAllergyMedicineAsthmaAllergic asthmaPathogenesisAllergenDiseasePathologyAsthma and respiratory diseasesIL-33, ST2, and ILC PathwaysEosinophilic Esophagitis