Disparities According to Genetic Ancestry in the Use of Precision Oncology Assays
Douglas A. Mata, Lisa S. Rotenstein, Marco A. Ramos, Anupam B. Jena
Abstract
concentrations in plasma (Table The highest plasma concentration of tecovirimat after one dose was 200 to 1000 times as high as the IC 50 values for the agent. The plasma concentrations of brincidofovir were 3.9 to 67.0 times as high as the IC 50 values, and the plasma concentrations of cidofovir were 2.5 to 16.0 times as high as the IC 50 values. Our data indicate that the currently circulating MPXVs are likely to remain sensitive to the available antiviral drugs.
Topics & Concepts
CidofovirPlasma concentrationInternal medicineOncologyPharmacologyMedicineVirologyVirusViral-associated cancers and disordersCancer Genomics and DiagnosticsVirus-based gene therapy research