Switching the hydrogenation selectivity of urea derivatives <i>via</i> subtly tuning the amount and type of additive in the catalyst system
Jun Zhu, Yongtao Wang, Jia Yao, Haoran Li
Abstract
-monomethylamines and methanol). Furthermore, changing the type of additive can also regulate this interesting selectivity. Control experiments showed that this selectivity is achieved by regulating the acid-base environment of the reaction to control the fate of the common hemiaminal intermediate. A feasible mechanism is proposed based on mechanistic experiments and characterization. This method has the advantages of being simple, universal and highly efficient, and opens up a new synthesis strategy for the utilization of renewable carbon sources.
Topics & Concepts
SelectivityCatalysisUreaChemistryCombinatorial chemistryOrganic chemistryChemical engineeringEngineeringAsymmetric Hydrogenation and CatalysisCatalysis for Biomass ConversionCatalysis and Hydrodesulfurization Studies