Recent Advances on Bacterial Cellulose-Based Wound Management: Promises and Challenges
Hedaiat Moradpoor, Hossein Mohammadi, Mohsen Safaei, Hamid Reza Mozaffari, Roohollah Sharifi, Pourya Gorji, Abu Bakar Sulong, Norhamidi Muhamad, Mona Ebadi
Abstract
Wound healing is a therapeutic challenge due to the complexity of the wound. Various wounds could cause severe physiological trauma and bring social and economic burdens to the patient. The conventional wound healing treatments using bandages and gauze are limited particularly due to their susceptibility to infection. Different types of wound dressing have developed in different physical forms such as sponges, hydrocolloids, films, membranes, and hydrogels. Each of these formulations possesses distinct characteristics making them appropriate for the treatment of a specific wound. In this review, the pathology and microbiology of wounds are introduced. Then, the most recent progress on bacterial cellulose- (BC-) based wound dressing discussed and highlighted their antibacterial and reepithelization properties in vitro and in vivo wound closure. Finally, the challenges and future perspectives on the development of BC-based wound dressing biomaterials are outlined.