Discovery of quinazoline derivatives as novel small-molecule inhibitors targeting the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interaction
Yu Wang, Kun Huang, Yali Gao, Dandan Yuan, Ling Lin, Jie‐Qing Liu, Si‐Hai Wu, Roufen Chen, He Li, Yizu Xiong, Han Liu, Junjie Ma
Topics & Concepts
ChemistryQuinazolineSmall moleculeDocking (animal)StereochemistryStructure–activity relationshipPyrimidineLead compoundLigand (biochemistry)IC50Programmed cell deathCombinatorial chemistryIn vitroBiochemistryReceptorApoptosisMedicineNursingQuinazolinone synthesis and applicationsCancer Immunotherapy and BiomarkersCAR-T cell therapy research