SIRT1 is downregulated by autophagy in senescence and ageing
Caiyue Xu, Lu Wang, Parinaz Fozouni, Gry Evjen, Vemika Chandra, Jing Jiang, Congcong Lu, Michael C. Nicastri, Corey Bretz, Jeffrey D. Winkler, Ravi K. Amaravadi, Benjamin A. García, Peter D. Adams, Mélanie Ott, Wei Tong, Terje Johansen, Zhixun Dou, Shelley L. Berger
Topics & Concepts
AutophagyCell biologySenescenceBiologyLysosomeHaematopoiesisDownregulation and upregulationImmune systemmTORC1Stem cellPI3K/AKT/mTOR pathwaySignal transductionBiochemistryImmunologyApoptosisEnzymeGeneSirtuins and Resveratrol in MedicineAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism