Dopamine Inputs from the Ventral Tegmental Area into the Medial Prefrontal Cortex Modulate Neuropathic Pain-Associated Behaviors in Mice

Abstract

(Cell Reports 31, 107812-1–107812-9.e1–e6; June 23, 2020) In the originally published version of this article, the bars in Figures 2D and 2E were incorrectly superimposed on the individual data points that reflect the experimental measurements. Figures 2D and 2E have now been corrected online and appear below. In Figure S3C, the individual data points superimposed on the green and red bars were accidentally swapped between the two conditions. In other words, the data points shown in the red bar should have been superimposed on the green bar and vice versa. Figure S3C has been corrected online and appears below. None of the statistical analysis of the data or interpretations of the findings were affected by this oversight. The authors regret these errors.Figure 2Phasic but Not Tonic Activation of DA Terminals in the mPFC Reduces Nerve Injury-Induced Hypersensitivity (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure S3Supplementary traces and statistics for fiber photometry (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure S3Supplementary traces and statistics for fiber photometry (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Dopamine Inputs from the Ventral Tegmental Area into the Medial Prefrontal Cortex Modulate Neuropathic Pain-Associated Behaviors in MiceHuang et al.Cell ReportsJune 23, 2020In BriefHuang et al. show that dopaminergic projections from the ventral tegmental area to the medial prefrontal cortex (mPFC) modulate pain responses in a mouse model of neuropathic pain. Dopamine enhances the activity of neurons projecting from mPFC layer 5 pyramidal neurons to the periaqueductal gray region, culminating in analgesia. Full-Text PDF Open Access

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