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Unveiling the potential of isatin-grafted phenyl-1,2,3-triazole derivatives as dual VEGFR-2/STAT-3 inhibitors: Design, synthesis and biological assessments

Heba A. Elsebaie, Maha‐Hamadien Abdulla, Zainab M. Elsayed, Moataz A. Shaldam, Haytham O. Tawfik, Samar N Morsy, Mansoor-Ali Vaali Mohammed, Thamer Bin Traiki, Eslam B. Elkaeed, Hatem A. Abdel‐Aziz, Wagdy M. Eldehna

2024Bioorganic Chemistry30 citationsDOI

Topics & Concepts

IsatinChemistrystatSTAT proteinRobustness (evolution)Activator (genetics)1,2,3-TriazoleCancer researchSTAT3Combinatorial chemistrySignal transductionBiochemistryReceptorBiologyGeneOrganic chemistryCancer Mechanisms and TherapyCAR-T cell therapy researchCytokine Signaling Pathways and Interactions
Unveiling the potential of isatin-grafted phenyl-1,2,3-triazole derivatives as dual VEGFR-2/STAT-3 inhibitors: Design, synthesis and biological assessments | Litcius