Peroxygenase‐Catalysed Selective Oxidation of Silanes to Silanols
Xiaomin Xu, Jacob M. A. van Hengst, Yejia Mao, Mireia Martinez, Sergi Rodà, Martin Floor, Vı́ctor Guallar, Caroline E. Paul, Miguel Alcalde, Frank Hollmann
Abstract
Abstract A peroxygenase‐catalysed hydroxylation of organosilanes is reported. The recombinant peroxygenase from Agrocybe aegerita ( Aae UPO) enabled efficient conversion of a broad range of silane starting materials in attractive productivities (up to 300 mM h −1 ), catalyst performance (up to 84 s −1 and more than 120 000 catalytic turnovers). Molecular modelling of the enzyme‐substrate interaction puts a basis for the mechanistic understanding of Aae UPO selectivity.
Topics & Concepts
SilanesChemistryHydroxylationCatalysisSilaneSubstrate (aquarium)SelectivityCombinatorial chemistryCatalytic efficiencyOrganic chemistryEnzymeOceanographyGeologyDiatoms and Algae ResearchMarine Biology and Environmental ChemistryPolyoxometalates: Synthesis and Applications