Antisense oligonucleotides increase <i>Scn1a</i> expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome
Han Zhou, Chunling Chen, Anne Christiansen, Sophina Ji, Qian Lin, Charles Anumonwo, Chanté Liu, Steven C. Leiser, Meena Meena, Isabel Aznarez, Gene Liau, Lori L. Isom
Abstract
1.1 protein was confirmed in brains of treated mice. Our results suggest that TANGO may provide a unique, gene-specific approach for the treatment of DS.
Topics & Concepts
Dravet syndromeOligonucleotideIncidence (geometry)MedicineEpilepsyCancer researchPharmacologyInternal medicineBiologyGeneGeneticsPsychiatryPhysicsOpticsEpilepsy research and treatmentNeonatal and fetal brain pathologyNeuroscience and Neuropharmacology Research